Witholding feeds during a blood transfusion in preterm infants

A review of five observational studies and one systematic review (of observational studies) found that withholding enteral feeds during a PRBC transfusion may reduce the risk of transfusion-associated NEC. None of the studies were randomized trials, all were unblinded, and the overall level of evidence for withholding feeds was low. Some cases of NEC did occur in infants who were NPO during transfusion, suggesting that the practice of withholding feeds, even if effective, will not eliminate transfusion-associated NEC completely.

Do feeding practices during transfusion influence the risk of NEC? Keir and Wilkinson, 2013