Treating Coagulase-negative Staph – is a three-day course enough?

In a NICU in the Netherlands the duration of treatment for Coagulase-negative Staphylococcal sepsis was changed from seven days to three days, provided that there was clinical improvement within 48 h, the CRP value decreased, the platelet count was normal, and central venous catheters were either absent or removed. Compared to infants treated previously with a seven-day regimen, infants treated with a three-day regimen had similar characteristics. All infants treated with the three-day regimen recovered fully, and none relapsed.

Shortening the Antibiotic Course for the Treatment of Neonatal Coagulase-Negative Staphylococcal Sepsis: Fine with Three Days? Hemels et al, 2012