Sustained lung inflation at birth

A randomized trial of babies 25 – 28 weeks gestation compared two methods of initial stabilization after birth – nasal CPAP alone versus sustained lung inflation followed by nasal CPAP. Infants receiving the sustained lung inflation had a lower incidence of mechanical ventilation in the first 72 hours (53% vs 65%). However this group also had a higher (not statistically significant) incidence of pneumothorax (6%) than control group infants (1%). There was no difference in the incidence of survival without BPD in the two groups.

Sustained lung inflation at birth for preterm infants: a randomized clinical trial. Lista et al 2015.