Spontaneous intestinal perforation, prophylactic indomethacin and early feeds

An observational study of nearly 16,000 extremely-low-birth-weight infants analyzed the rates of spontaneous intestinal perforation in extremely-low-birth-weight infants, some of whom were exposed to prophylactic indomethacin or early feedings, or both. In those treated with prophylactic indomethacin, the risk of SIP was similar in infants receiving early feedings versus not. In those not treated with prophylactic indomethacin, the risk of SIP was lower in infants receiving early feedings versus not. Overall, the risk of SIP was lower in infants receiving indomethacin and early feeding, compared to those receiving neither of these.

Prophylactic indomethacin and intestinal perforation in ELBW infants. Kelleher et al, 2014.