Severe hyperbilirubinemia and its effects

A retrospective review of over half a million births at a gestation of 35 weeks or greater over a 16-year period found that the incidence of severe hyperbilirubinemia (total serum bilirubin 30 mg/dl or higher) was 9 per 100,000 births. The etiology was not identified in 70% of the 47 cases identified. Among infants in whom glucose-6-phosphate dehydrogenase activity was measured, approximately 40% were deficient. Of the 47 infants, on long-term follow-up, two developed cerebral palsy with sensorineural hearing loss, while another two infants developed just sensorineural hearing loss (more than 90% escaped neurodevelopmental sequelae).

Incidence, etiology and outcomes of hazardous hyperbilirubinemia in newborns. Kuzniewicz et al, 2014