Prognostic tests in HIE

A systematic review of prognostic tests in term infants with hypoxic ischemic encephalopathy included 29 studies of 13 different tests to predict long-term neurologic sequelae or death. Amplitude-integrated EEG and visual evoked potentials had the best sensitivity and specificity (around 90% each). The EEG had a sensitivity of around 90% and specificity of around 80%. Among imaging tests, diffusion weighted MRI had the best specificity (around 90%) and T1/T2-weighted MRI had the best sensitivity (close to 100%). Magnetic resonance spectroscopy had a sensitivity of 75% and had poor specificity (60%). There was a lot of heterogeneity in the performance of the tests, the cut-off values, and in the outcomes measured.

Prognostic tests in term neonates with HIE: a systematic review. van Laerhoven 2013.