A multicenter randomized study in 39 NICUs (the largest trial of its kind) compared the effects of applying polyethylene occlusive wrap to preterm infants between 24 – 27 weeks gestation immediately after birth. The study was stopped early when 50% of the sample size had been enrolled, because analysis showed that continued enrollment was unlikely to show a difference in the primary outcome. The study also had multiple protocol violations. Infants who were placed in the wrap had a higher baseline temperature, higher post-stabilization temperature, a lower mean Apgar score at one minute, and a lower frequency of pulmonary hemorrhage than infants who did not receive the wrap. However there was no significant difference in mortality (the primary outcome) between the two groups.