Occlusive wrap to prevent heat loss at birth

A multicenter randomized study in 39 NICUs (the largest trial of its kind) compared the effects of applying polyethylene occlusive wrap to preterm infants between 24 – 27 weeks gestation immediately after birth. The study was stopped early when 50% of the sample size had been enrolled, because analysis showed that continued enrollment was unlikely to show a difference in the primary outcome. The study also had multiple protocol violations. Infants who were placed in the wrap had a higher baseline temperature, higher post-stabilization temperature, a lower mean Apgar score at one minute, and a lower frequency of pulmonary hemorrhage than infants who did not receive the wrap. However there was no significant difference in mortality (the primary outcome) between the two groups.

Randomized trial of occlusive wrap for heat loss prevention in preterm infants. Reilly et al.2014