Nasal CPAP after extubation

A randomized trial of preterm babies 500 – 1000 grams birth weight being extubated for the first time compared the use of high (7 – 9 cms) versus low (4 – 6 cms) nasal CPAP levels. Each arm of the trial included nearly 50 babies, and babies on average were just over two weeks old. Infants managed with high nCPAP had a lower rate of extubation failure (24% vs 43%) and lower rate of reintubation (17% vs 48%) within 96 hours. Other clinical outcomes such as bronchopulmonary dysplasia were not different between the two groups.

A randomized controlled trial of two nasal CPAP levels after extubation. Buzzella et al, 2014.