A systematic review examined the association between maternal therapy with antidepressants and neonatal persistent pulmonary hypertension (PPHN). Seven studies were included. Quantitative analysis was possible only for studies using selective serotonin uptake inhibitors. Exposure to SSRIs late in pregnancy was found to increase the risk of PPHN in the neonates (odds ratio 2.5), but this association was not found with treatment in early pregnancy. The absolute risk of neonatal PPHN was low – for approximately 300 mothers treated with SSRIs late in pregnancy, one additional infant would develop PPHN.