Long-term outcomes of total body hypothermia

The Total Body Hypothermia for Neonatal Encephalopathy (TOBY) randomized trial previously showed beneficial effects with therapeutic hypothermia at 18 months follow-up. The infants in these trial were followed until 6 – 7 years of age. Infants undergoing hypothermia treatment were found to have higher rates of intact survival (survival with an IQ score of 85 or more) than control infants (52% vs 39%). Around 30% of the infants in each group died. Among survivors, infants who were cooled had lower rates of neurodevelopmental impairment than controls.

Moderate hypothermia to treat perinatal asphyxial encephalopathy. Azzopardi et al, 2014.