A case series from France reports on the use of intranasal midazolam as pre-medication for intubation of preterm infants to administer surfactant soon after birth. Twenty-seven infants with a median gestation of 29 weeks were studied. Infants were monitored using pain scales, electrical skin conductance, pulse oximetry and blood pressure measurement. Intubation was performed at a median of five minutes after midazolam administration. Two-thirds of the infants had adequate comfort during the procedure, but the mean blood pressure decreased as well.