How much evidence exists about neonatal seizure management?

A systematic review of all articles listed in Pubmed upto 2011 describing treatment of neonatal seizures (only studies with seizures confirmed electrographically were included) found there was scant evidence to support choice of treatments for neonatal seizures. Only two randomized trials were identified and there were only three additional studies that included any comparison groups. The authors propose a treatment algorithm for seizures.

Pharmacological treatment of seizures – a systematic review. Slaughter et al, 2013.