A randomized controlled noninferiority trial from a single center in Nigeria compared, in infants with hyperbilirubinemia, the use of conventional phototherapy against filtered sunlight. Over two hundred infants were assigned to each group. Efficacy was defined as a slowing of rate of rise of serum bilirubin in infants up to 72 hours old, and a decrease after 72 hours of age. Safety outcomes such as hyperthermia and sunburn were also assessed. Filtered sunlight was noninferior to conventional phototherapy, had a higher mean level of irradiance (40 vs. 17 μW per square centimeter per nanometer), and did not result in any study withdrawals for reasons of safety. Around 90% of infants in both groups responded well to therapy.