Exclusive human milk diet versus cows milk formula and fortifier

A multicenter randomized trial in extremely preterm infants compared a feeding regimen based exclusively on human milk (donor breast milk with fortifier derived from human milk) to one using preterm formula and fortifier derived from cows milk. Infants were eligible if their mothers did not provide their own breast milk. Infants fed with the human milk regimen had a shorter duration of parenteral nutrition and a lower rate of surgical NEC, but the rate of NEC overall was not statistically different in the two groups. The incidence of NEC in the group fed formula was very high (21%), much higher than the usual rate of NEC.

Exclusive human milk versus preterm formula diet in extremely premature infants. Cristofalo et al, 2013.