In a retrospective cohort study from Canadian NICUs of babies less than 29 weeks gestation or less than 1000 grams birth weight who had a percutaneously placed central venous catheter, around 20% of babies developed catheter-related sepsis. The rate of CRS varied widely between centers. Some centers has 0 and other had upto 37 infections per 1000 catheter days. The daily risk of catheter-related sepsis varied between 1 – 2 % in the first 28 days. No threshold of catheter usage duration could be identified above which the risk of infection increased. Infected babies had a longer length of stay (almost a week longer) but no increased risk of death or morbidity compared to those without infection.