Category: Hematology

Venous thrombosis in neonates

Venous thromboembolism is being increasingly diagnosed in neonates and is the result of a disturbance of the delicate balance between procoagulant and anticoagulant factors in neonatal blood. The primary risk factors are the use of central venous catheters, and prematurity.…

RBC transfusion variability in NICUs

A retrospective analysis of data from four NICUs that were following the same RBC transfusion guidelines showed wide variability in the number of RBC transfusions administered, from 5 per 1000 NICU days to 22 per 1000 NICU days. NICUs with…

Witholding feeds during a blood transfusion in preterm infants

A review of five observational studies and one systematic review (of observational studies) found that withholding enteral feeds during a PRBC transfusion may reduce the risk of transfusion-associated NEC. None of the studies were randomized trials, all were unblinded, and the…

Neonatal thrombocytopenia and platelet transfusions

A review article from Oxford summarizes recent evidence on thrombocytopenia and its treatment, emphasizing the lack of evidence on this topic. Approximately 25% of NICU patients develop thrombocytopenia. A pragmatic definition of neonatal thrombocytopenia is a platelet count less than…

Does PRBC transfusion increase the risk of NEC?

A systematic review with a meta-analysis of eleven observational studies evaluated whether PRBC transfusions were associated with an increased risk of NEC in the 48 hours following the transfusion. Most of these studies had a low or moderate risk of…