Benign transient non-organic ileus of neonates

Benign transient non-organic ileus of neonates (BTNIN) is a condition that mimics Hirschsprung disease clinically and radiographically, but is not associated with aganglionic bowel. Surgery is not required and only conservative treatment is required. A retrospective review of 19 neonates with BTNIN from Korea describes the common presentations of this condition – abdominal distension, emesis, explosive defecation, and constipation. Infants usually presented between two and four weeks of life. Radiologic findings were similar to Hirschsprung’s disease, with a contrast enema showing a transition zone in one-third of patients. The majority of patients had ganglion cells on rectal biopsy and a normal rectoanal inhibitory reflex on¬†anorectal manometry. With¬†conservative treatment all patients improved by around five months of life.

Benign transient non-organic ileus of neonates. Chang et al, 2014.